Yakin Issus tsohon soja ne da ya faru a shekara ta 333 kafin haihuwar Annabi Isa, tsakanin Alexander the Great na Makedon da Sarkin Farisa Darius na uku. Kalmar “Issus” tana nufin wani birni a ƙasar Kilisiya ta dā (yanzu a Turkiyya ta zamani) inda aka yi yaƙin.
